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Hydroxyurea significantly improves the frequency of sickle cell crisis, but it has a long list of adverse effects. But if the dose is monitored properly and complete blood count of patient is done on regular basis, than some of the adverse effects can be easily identified and managed accordingly.

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Genetic testing can identify parents at risk for having a child with sickle cell disease.

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Hanna echoed that concern and added that a stigma is associated with sickle cell disease, in part because it affects mostly African Americans and other minorities.

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Dr Lorna Bennett, Chairperson, Sickle Cell Society said: ' The reality is that provision of care for adults with sickle cell disease can vary significantly between individual professionals as well as health care provision organisations.

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Similarly, increased surface expression of the activation markers CD69, CD25, and HLA-DR was detected by flow cytometry on eosinophils from patients with FE compared with NL, albeit less than that seen in HES.

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