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I dreaded the side-effects and had NONE. I had the intravenous infusion three days before Christmas 2011 and was scared that I would be flattened by the supposed side-effects like flu-like symptoms, bone ache and so forth and was pleasantly surprised. I am having my second one in just ten days time and hopefully it will be a repeat of the first one.
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I like the convenience of only having to take the once a year infusion. I have had no noticeable side effects.

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Just had my second Prolia injection and no side effects that I can blame on it as of yet.

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Given the relatively poor adherence to oral bisphosphonate therapy in clinical practice, annual infusion of zoledronic acid may provide a promising approach to reducing fracture risk.

Reclast, Skelid, and Zometa) in the past; if you have ever had surgery on your parathyroid gland (small gland in the neck) or thyroid gland or surgery to remove sections of your small intestine; and if you have or have ever had heart failure (condition in which the heart cannot pump enough blood to other parts of the body); anemia (condition in which red blood cells cannot bring enough oxygen to other parts of the body); any condition that stops your blood from clotting normally; low levels of calcium, magnesium, or potassium in your blood; any condition that prevents your body from absorbing nutrients from food; or problems with your mouth, teeth, or gums; an infection, especially in your mouth; asthma or wheezing, especially if it is made worse by taking aspirin; or parathyroid or liver disease.

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This complication is not common, and the benefit of overall fracture reduction still holds.

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Secondary end points were the proportion of men with one or more new morphometric vertebral fractures over 12 months; one or more new moderate-to-severe, or new or worsening morphometric vertebral fractures over 12 and 24 months; a change in height at months 12 and 24; the time to first clinical fracture (vertebral or nonvertebral); and changes from baseline in bone mineral density at the lumbar spine, total hip, and femoral neck and in bone-turnover markers.

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Further clinical experience is needed to confirm that these characteristics can have an impact on fracture protection.

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According to a position paper by the American Association of Maxillofacial Surgeons (AAOMS), MRONJ has been associated with bisphosphonates and other antiresorptive agents (denosumab), and antiangiogenic agents (eg, bevacizumab, sunitinib) used for the treatment of osteoporosis or malignancy; risk is significantly higher in cancer patients receiving antiresorptive therapy compared to patients receiving osteoporosis treatment (regardless of medication used or dosing schedule).

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Strontium-Citrate is a dual-action agent that has been shown to increase bone density 8%-14% over a three year period.

Will be getting a another bone density test soon hoping the save our bones program helped me.

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One year later on 10-09-08 I had a second Dexa scan performed at the same office with the same machine, and my hip increased to -2.

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